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Annals of Molecular and Genetic Medicine Submit Manuscript
ISSN: 2692-4595

ISSN: 2692-4595

Annals of Molecular and Genetic Medicine

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    Executive Editors

    Wei Wu
    Associate Department Chair
    Department of Toxicology
    Nanjing Medical University
    China
    epigenetic@126.com
    AMGM

    Dr. Wei Wu is an Associate Professor and Associate Department Chair in the Department of Toxicology at Nanjing Medical University, China, where he received his Ph.D. in Toxicology in 2012. He was a guest researcher at the National Institute of Environmental Health Sciences (NIEHS) between 2017 and 2018.
    He is a member of different national and international societies in the fields of human reproduction and toxicology, and has received awards from many national societies for the originality and quality of his projects. He has a wide range of teaching and consulting experience, including in the area of toxicology. His research interests include epigenetic mechanisms of transgenerational effects of male infertility induced by endocrine disrupting chemicals, environmental exposure, and male reproductive health, genetic and epigenetic risk factors of male infertility and abnormal fetal growth.
    Prof. Wu has authored 72 peer-reviewed papers in international journals such as EBioMedicine, Clinical Epigenetics, Environment International, Toxicological Sciences, Scientific Reports, Human Reproduction, and Molecular Human Reproduction. He has edited four books and collaborated on ten books, 11 patents and in the organization of three international conferences. He is a reviewer of 62 journals. Prof. Wu serves as the Editor-in-Chief of an international scientific journal International Journal of Sexual Health and Reproductive Health Care, Executive Editor of Annals of Molecular and Genetic Medicine, Associate Editor of the JSM Invitro Fertilization, and editor of many other journals including Scientific Reports and Medicine.
    Research Interest:     Dr. Wei Wu research interests includes male reproductive health, reproductive toxicology, pregnancy complications, abnormal birth outcomes, epigenetics and fetal growth, genetics, polymorphism, reproductive epidemiology, and environmental epidemiology.

    Grants:

    1）    Major Project of Natural Science Research in Jiangsu Province Colleges and Universities in 2020 (20KJA330001): the role of miR-206/Ehhadh in the intergenerational inheritance of spermatogenesis from exposure to pregnancy DBP and its mechanism ,2021/1-2023/12, ￥150,000.

    2）    Medical Research Project of Jiangsu Health and Health Commission (Z2019010): study on the mechanism of transgenerational inheritance of spermatogenesis induced by metabolic pathway changes in intrauterine DBP exposure 2020/1-2022/12, ￥10,000.

    3）    National key research and development project: The establishment and basic research for application of China Assisted reproductive birth cohort population and the offspring cohort of the Chinese population. 2016/7-2021/6, ￥280,900.

    4）    National Natural Science Foundation of China (81673217): The study of role and molecular mechanisms of the DSTF1/miR-125-3p/Fstl3 pathway in the transgenerational spermatogenic failure caused by prenatal DBP exposure. 2017/1-2020/12, ￥600,000.

    5）    China Postdoctoral Science Foundation (2015T80571): The role and molecular mechanisms of human miR-483-3p in the BP-3 induced fetal macrosomia. 2015/7-2017/6, ￥150,000.

    6）    National Natural Science Foundation of China (81302457): Effect and mechanism of miR-17-92 gene cluster in spermatogenic failure induced by genistein exposure. 2014/1-2016/12, ￥240,000.

    7）    Jiangsu Natural Science Foundation (BK20130894): The role and molecular mechanisms of miR-200s family in spermatogenic failure induced by genistein exposure. 2013/7-2016/6, ￥200,000.

    8）    China Postdoctoral Science Foundation (2013M531388): The role and molecular mechanism of imprinted lncRNA-H19 in fetal growth restriction. 2013/3-2015/2, ￥50,000.

    9）    Science and Technology Development Fund Key Project of Nanjing Medical University (2012NJMU002): Environment and epigenetics risk factors and their interactions in spermatogenic failure. 2012/12-2014/12, ￥30,000.

    List of Publications:

    1）    Guan Q, Chen S, Wang B, Dou X, Lu Y, Liang J, Ni R, Yang C, Wang H, Baktash MB, Wu W, Wang X, Fu G, Xia Y. Effects of particulate matter exposure on semen quality: A retrospective cohort study. Ecotoxicol Environ Saf. 2020; 193:110319.
    2）    Yuan B, Wu W, Zhang H, Gu H, Guo D, Jiang J, Wang X. Adenomatous polyposis coli as a predictor of environmental chemical-induced transgenerational effects related to male infertility. J Biochem Mol Toxicol. 2019 Jul;33(7):e22331.
    3）    Tang Q, Gui J, Wu X, Wu W*. Downregulation of miR-424 in placenta is associated with severe preeclampsia. Pregnancy Hypertens. 2019; 17:109-112.
    4）    Tang Q, Pan F, Wu X, Nichols CE, Wang X, Xia Y, London SJ, Wu W*. Semen quality and cigarette smoking in a cohort of healthy fertile men. Environ Epidemiol. 2019; (32019)3:e055.
    5）    Han X, Wang Y, Chen T, Wilson MJ, Pan F, Wu X, Rui C, Chen D, Tang Q, Wu W*. Inhibition of progesterone biosynthesis induced by deca-brominated diphenyl ether (BDE-209) in mouse Leydig tumor cell (MLTC-1). Toxicol In Vitro. 2019; 60:383-388.
    6）    Guo D, Jiang H, Chen Y, Yang J, Fu Z, Li J, Han X, Wu X, Xia Y, Wang X, Chen L, Tang Q, Wu W*. Elevated microRNA-141-3p in placenta of non-diabetic macrosomia regulate trophoblast proliferation. EBioMedicine. 2018; 38:154-161. (Cover Article)
    7）    Tang Q, Pan F, Yang J, Fu Z, Lu Y, Wu X, Han X, Chen M, Lu C, Xia Y, Wang X, Wu W*. Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: a case-control study. Clin Epigenetics. 2018; 10(1):134.
    8）    Li J, Fu Z, Jiang H, Chen L, Wu X, Ding H, Xia Y, Wang X, Tang Q, Wu W*. IGF2-derived miR-483-3p contributes to macrosomia through regulating trophoblast proliferation by targeting RB1CC1. Mol Hum Reprod. 2018; 24(9):444-452.
    9）    Zhou R, Zhang Y, Du G, Han L, Zheng S, Liang J, Huang X, Qin Y, Wu W, Chen M, Wu D, Song L, Fu G, Lv S, Xia Y, Lu C, Wang X. Down-regulated let-7b-5p represses glycolysis metabolism by targeting AURKB in asthenozoospermia. Gene. 2018; 663:83-87.
    10）    Chen M, Ni C, Hu Y, Wang M, Liu L, Ji X, Chu H, Wu W, Lu C, Wang S, Wang S, Zhao L, Li Z, Zhu H, Wang J, Xia Y, Wang X. Meta-analysis on the effectiveness of team-based learning on medical education in China. BMC Med Educ. 2018;18(1):77.
    11）    Han Y, Ji Y, Kang S, Dong T, Zhou Z, Zhang Y, Chen M, Wu W, Tang Q, Chen T, Wang Y, Xia Y. Effects of particulate matter exposure during pregnancy on birth weight: A retrospective cohort study in Suzhou, China. Sci Total Environ. 2018; 615:369-374.
    12）    Yuan B, Wu W*, Chen M, Gu H, Tang Q, Guo D, Chen T, Chen Y, Lu C, Song L, Xia Y, Chen D, Rehan V, Sha J, Wang X*. Metabolomics reveals a role of betaine in prenatal DBP exposure-induced epigenetic transgenerational failure of spermatogenesis in rats. Toxicol Sci. 2017; 158 (2): 356-366. (Cover Article)
    13）    Tang Q, Chen Y, Wu W*, Ding H, Xia Y, Chen D, Wang X. Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking. Sci Rep. 2017; 7(1):11219.
    14）    Wang L, Hu W, Guan Q, Du G, Chen T, Wu W, Wang Y, Wang X, Xia Y. The association between cooking oil fume exposure during pregnancy and birth weight: A prospective mother-child cohort study. Sci Total Environ. 2017; 612:822-830.
    15）    Qiao S, Wu W (co-first author), Chen M, Tang Q, Xia Y, Jia W, Wang X. Seminal plasma metabolomics approach for the diagnosis of unexplained male infertility. PLoS One. 2017; 12(8):e0181115.
    16）    Hu W, Chen M, Ji J, Qin Y, Zhang F, Xu M, Wu W, Du G, Wu D, Han X, Jin L, Xia Y, Lu C, Wang X. Interaction between Y chromosome haplogroup O3* and 4-n-octylphenol exposure reduces the susceptibility to spermatogenic impairment in Han Chinese. Ecotoxicol Environ Saf. 2017; 144:450-455.
    17）    Pan L, Liu Q, Li J, Wu W, Wang X, Zhao D, Ma J. Association of the VDAC3 gene polymorphism with sperm count in Han-Chinese population with idiopathic male infertility. Oncotarget. 2017; 8(28):45242-45248.
    18）    Chang C, Chen M, Gao J, Luo J, Wu K, Dong T, Zhou K, He X, Hu W, Wu W, Lu C, Hang B, Meeker JD, Wang X, Xia Y. Current pesticide profiles in blood serum of adults in Jiangsu Province of China and a comparison with other countries. Environ Int. 2017; 102:213-222.
    19）    Gu H, Wu W*, Yuan B, Tang Q, Guo D, Chen Y, Xia Y, Hu L, Chen D, Sha J, Wang X. Genistein up-regulates miR-20a to disrupt spermatogenesis via targeting Limk1. Oncotarget. 2017; 8(35):58728-58737.
    20）    Guo D, Wu W*, Tang Q, Qiao S, Chen Y, Chen M, Teng M, Lu C, Ding H, Xia Y, Hu L, Chen D, Sha J, Wang X. The impact of BMI on sperm parameters and the metabolite changes of seminal plasma concomitantly. Oncotarget. 2017; 8(30):48619-48634.
    21）    Chen T, Xu J, Liu G, Liu H, Chen M, Qin Y, Wu W, Xia Y, Ji C, Guo X, Wen J, Wang X. Genetic variants in PTPRD and risk of gestational diabetes mellitus. Oncotarget. 2016; 7(46):76101-76107.
    22）    Ji J, Qin Y, Zhou R, Zang R, Huang Z, Zhang Y, Chen M, Wu W, Song L, Ling X, Shen H, Hu Z, Xia Y, Lu C, Wang X. X chromosome-wide identification of SNVs in microRNA genes and non-obstructive azoospermia risk in han chinese population. Oncotarget. 2016; 7(31):49122-49129.
    23）    Chang J, Pan F, Tang Q, Wu W*, Chen M, Lu C, Ding H, Hu L, Chen D, Xia Y, Wang X. eNOS gene T786C, G894T and 4a4b polymorphisms and male infertility susceptibility: a meta-analysis. Andrologia. 2016; 49(4).
    24）    Hu W, Chen M, Wu W*, Lu J, Zhao D, Pan F, Lu C, Xia Y, Hu L, Chen D, Sha J, Wang X. Gene-gene and gene-environment interactions on risk of male infertility: Focus on the metabolites. Environ Int. 2016; 91:188-195.
    25）    Pan B, Li R, Chen Y, Tang Q, Wu W*, Chen L, Lu C, Pan F, Ding H, Xia Y, Hu L, Chen D, Sha J, Wang X. Genetic Association Between Androgen Receptor Gene CAG Repeat Length Polymorphism and Male Infertility: A Meta-Analysis. Medicine (Baltimore). 2016; 95(10):e2878.
    26）    Yuan B, Gu H, Xu B, Tang Q, Wu W*, Ji X, Xia Y, Hu L, Chen D, Wang X. Effects of Gold Nanorods on Imprinted Genes Expression in TM-4 Sertoli Cells. Int J Environ Res Public Health. 2016; 13(3). pii: E271.
    27）    Lu J, Gu H, Tang Q, Wu W*, Yuan B, Guo D, Wei Y, Sun H, Xia Y, Ding H, Hu L, Chen D, Sha J, Wang X. Common SNP in hsa-miR-196a-2 increases hsa-miR-196a-5p expression and predisposes to idiopathic male infertility in Chinese Han population. Sci Rep. 2016; 6:19825.
    28）    Zhou R, Wang R, Qin Y, Ji J, Xu M, Wu W, Chen M, Wu D, Song L, Shen H, Sha J, Miao D, Hu Z, Xia Y, Lu C, Wang X. Mitochondria-related miR-151a-5p reduces cellular ATP production by targeting CYTB in asthenozoospermia. Sci Rep. 2015; 5:17743.
    29）    Li J, Chen L, Tang Q, Wu W*, Gu H, Liu L, Wu J, Jiang H, Ding H, Xia Y, Chen D, Hu Y, Wang X. The role, mechanism and potentially novel biomarker of microRNA-17-92 cluster in macrosomia. Sci Rep. 2015; 5:17212.
    30）    Ji J, Qin Y, Ren J, Lu C, Wang R, Dai X, Zhou R, Huang Z, Xu M, Chen M, Wu W, Song L, Shen H, Hu Z, Miao D, Xia Y, Wang X. Mitochondria-related miR-141-3p contributes to mitochondrial dysfunction in HFD-induced obesity by inhibiting PTEN. Sci Rep. 2015; 5:16262.
    31）    Ju R, Wu W (co-first author), Tang Q, Wu D, Xia Y, Wu J, Wang X. Association Analysis between the Polymorphisms of HSD11B1 and H6PD and Risk of Polycystic Ovary Syndrome in Chinese Population. PLoS One. 2015; 10(10):e0140326.
    32）    Lu C, Xu M, Wang R, Qin Y, Ren J, Wu W, Song L, Wang S, Zhou Z, Shen H, Sha J, Hu Z, Xia Y, Miao D, Wang X. A genome-wide association study of mitochondrial DNA in Chinese men identifies two risk single nucleotide substitutions for idiopathic oligoasthenospermia. Mitochondrion. 2015; 24:87-92.
    33）    Tang W, Tang J, He J, Zhou Z, Qin Y, Qin J, Li B, Xu X, Geng Q, Jiang W, Wu W, Wang X, Xia Y. SLIT2/ROBO1-miR-218-1-RET/PLAG1: a new disease pathway involved in Hirschsprung's disease. J Cell Mol Med. 2015; 19(6):1197-207.
    34）    Ju R, Wu W (co-first author), Fei J, Qin Y, Tang Q, Wu D, Xia Y, Wu J, Wang X. Association analysis between the polymorphisms of HSD17B5 and HSD17B6 and risk of polycystic ovary syndrome in Chinese population. Eur J Endocrinol. 2015; 172(3):227-33.
    35）    Tang W, Li H, Tang J, Wu W, Qin J, Lei H, Cai P, Huo W, Li B, Rehan V, Xu X, Geng Q, Zhang H, Xia Y. Specific serum microRNA profile in the molecular diagnosis of Hirschsprung's disease. J Cell Mol Med. 2014; 18(8):1580-7.
    36）    Zhao M, Tang Q, Wu W (corresponding author), Xia Y, Chen D, Wang X. miR-20a contributes to endometriosis by regulating NTN4 expression. Mol Biol Rep. 2014; 41(9):5793-7.
    37）    Jiang H, Wu W (co-first author), Zhang M, Li J, Peng Y, Miao T, Zhu H, Xu G. Aberrant upregulation of miR-21 in placental tissues of macrosomia. J Perinatol. 2014; 34(9):658-63.
    38）    Zhang S, Tang Q, Wu W*, Yuan B, Lu C, Xia Y, Ding H, Hu L, Chen D, Sha J, Wang X. Association between DAZL polymorphisms and susceptibility to male infertility: systematic review with meta-analysis and trial sequential analysis. Sci Rep. 2014; 4:4642.
    39）    Qin Y, Ji J, Du G, Wu W, Dai J, Hu Z, Sha J, Hang B, Lu C, Xia Y, Wang X. Comprehensive pathway-based analysis identifies associations of BCL2, GNAO1 and CHD2 with non-obstructive azoospermia risk. Hum Reprod. 2014; 29(4):860-6.
    40）    Qin Y, Du G, Chen M, Hu W, Lu C, Wu W, Hang B, Zhou Z, Wang X, Xia Y. Combined effects of urinary phytoestrogens metabolites and polymorphisms in metabolic enzyme gene on idiopathic male infertility. Arch Toxicol. 2014; 88(8):1527-36.
    41）    Zhou Z, Qin J, Tang J, Li B, Geng Q, Jiang W, Wu W, Rehan V, Tang W, Xu X, Xia Y. Down-regulation of MeCP2 in Hirschsprung's disease. J Pediatr Surg. 2013; 48(10):2099-2105.
    42）    Tang W, Qin J, Tang J, Zhang H, Zhou Z, Li B, Geng Q, Wu W, Xia Y, Xu X. Aberrant reduction of MiR-141 increased CD47/CUL3 in Hirschsprung's disease. Cell Physiol Biochem. 2013; 32(6):1655-67.
    43）    Xu M, Qin Y, Qu J, Lu C, Wang Y, Wu W, Song L, Wang S, Chen F, Shen H, Sha J, Hu Z, Xia Y, Wang X. Evaluation of Five Candidate Genes from GWAS for Association with Oligozoospermia in a Han Chinese Population. PLoS One. 2013; 8(11):e80374.
    44）    Lu C, Xu M, Wang R, Qin Y, Wang Y, Wu W, Song L, Wang S, Shen H, Sha J, Miao D, Hu Z, Xia Y, Wang X. Pathogenic variants screening in five non-obstructive azoospermia-associated genes. Mol Hum Reprod. 2013; 20(2):178-83.
    45）    Tang Q, Li J, Zhang S, Yuan B, Sun H, Wu D, Lu C, Wu W (corresponding author), Xia Y, Ding H, Hu L, Chen D*, Sha J*, Wang X. GSTM1 and GSTT1 Null Polymorphisms and Childhood Acute Leukemia Risk: Evidence from 26 Case-Control Studies. PLoS One. 2013; 8(10):e78810.
    46）    Xu S, Xu P, Wu W, Ou Y, Xu J, Zhang G, Li J, Xu G. The biphasic expression pattern of miR-200a and E-cadherin in epithelial ovarian cancer and its correlation with clinicopathological features. Curr Pharm Des. 2014; 20(11):1888-95.
    47）    Wu W*, Lu J, Tang Q, Zhang S, Yuan B, Li J, Di Wu, Sun H, Lu C, Xia Y, Chen D, Sha J, Wang X. GSTM1 and GSTT1 null polymorphisms and male infertility risk: an updated meta-analysis encompassing 6934 subjects. Sci Rep. 2013; 3:2258.
    48）    Xu C, Song RJ, Yang J, Jiang B, Wang XL, Wu W, Zhang W. Klotho gene polymorphism of rs3752472 is associated with the risk of urinary calculi in the population of Han nationality in Eastern China. Gene. 2013; 526(2):494-7.
    49）    Lu C, Wang Y, Zhang F, Lu F, Xu M, Qin Y, Wu W, Li S, Song L, Yang S, Wu D, Jin L, Shen H, Sha J, Xia Y, Hu Z, Wang X. DAZ duplications confer the predisposition of Y chromosome haplogroup K* to non-obstructive azoospermia in Han Chinese populations. Hum Reprod. 2013; 28(9):2440-9.
    50）    Wu W*, Lu J, Chen D, Yuan B, Qin Y, Han X, Niu X, Xu B, Lu C, Xia Y, Sha J, Wang X. Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure. Gene. 2013; 524:197-202.
    51）    Tang W, Li B, Tang J, Liu K, Qin J, Wu W, Geng Q, Zhang J, Chen H, Xu X, Xia Y. Methylation analysis of EDNRB in human colon tissues of Hirschsprung's disease. Pediatr Surg Int. 2013; 29:683-8.
    52）    Lv Q, Lu J, Wu W, Sun H, Zhang J. Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with stroke risk based on a meta-analysis. Genet Mol Res. 2013; 12(4):6882-94.
    53）    Wu W, Qin Y, Li Z, Dong J, Dai J, Lu C, Guo X, Zhao Y, Zhu Y, Zhang W, Sha J, Shen H, Xia Y, Hu Z, Wang X. Genome-wide microRNA expression profiling in idiopathic non-obstructive azoospermia: significant up-regulation of miR-141, miR-429 and miR-7-1-3p. Hum Reprod. 2013; 28:1827-36.
    54）    Qin Y, Chen M, Wu W (co-first author), Xu B, Tang R, Chen X, Du G, Lu C, Meeker JD, Zhou Z, Xia Y, Wang X. Interactions between Urinary 4-tert-Octylphenol Levels and Metabolism Enzyme Gene Variants on Idiopathic Male Infertility. PLoS One. 2013; 8:e59398.
    55）    Tang Q, Wu W (co-first author), Xu X, Huang L, Gao Q, Chen H, Sun H, Xia Y, Sha J, Wang X, Chen D, Xu Q. miR-141 Contributes to Fetal Growth Restriction by Regulating PLAG1 Expression. PLoS One. 2013; 8:e58737.
    56）    Lu C, Xu M, Wang Y, Qin Y, Du G, Wu W, Han X, Ji C, Yang Y, Gu A, Xia Y, Song L, Wang S, Wang X. Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population. PLoS One. 2013; 8:e53443.
    57）    Xu S, Wu W (co-first author), Sun H, Lu J, Yuan B, Xia Y, Moor B, Marchal K, Wang X, Xu P, Cheng W. Association of the vascular endothelial growth factor gene polymorphisms (-460C/T, +405G/C, and +936T/C) with endometriosis: a meta-analysis. Ann Hum Genet. 2012; 76:464-471.
    58）    Chen M, Xu B, Ji W, Qiao S, Hu N, Hu Y, Wu W, Qiu L, Zhang R, Wang Y, Wang S, Zhou Z, Xia Y, Wang X. Bisphenol A Alters n-6 Fatty Acid Composition and Decreases Antioxidant Enzyme Levels in Rat Testes: A LC-QTOF-Based Metabolomics Study. PLoS One. 2012; 7:e44754.
    59）    Tang W, Li B, Xu X, Zhou Z, Wu W, Tang J, Qin J, Geng Q, Jiang W, Zhang J, Sha J, Xia Y, Wang X. Aberrant high expression of NRG1 gene in Hirschsprung disease. J Pediatr Surg. 2012; 47:1694-8.
    60）    Han X, Tang R, Chen X, Xu B, Qin Y, Wu W, Hu Y, Xu B, Song L, Xia Y, Wang X. 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47) decreases progesterone synthesis through cAMP-PKA pathway and P450scc downregulation in mouse Leydig tumor cells. Toxicology. 2012; 302:44-50.
    61）    Zhao D, Wu W (co-first author), Xu B, Niu X, Cui H, Zhang Y, Wang Z, Wang X. Variants in the SRD5A2 gene are associated with quality of semen. Mol Med Report. 2012; 6:639-44.
    62）    Wu W, Hu Z, Qin Y, Dong J, Dai J, Lu C, Zhang W, Shen H, Xia Y, Wang X. Seminal plasma microRNAs: potential biomarkers for spermatogenesis status. Mol Hum Reprod. 2012; 18:489-97.
    63）    Wu W, Cai H, Sun H, Lu J, Zhao D, Qin Y, Han X, Niu X, Lu C, Xia Y, Wang S, De Moor B, Marchal K, Wang X. Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility: A meta-analysis. Gene. 2012; 505:388-92.
    64）    Qin Y, Xia Y, Wu W, Han X, Lu C, Ji G, Chen D, Wang H, Song L, Wang S, Wang X. Genetic variants in microRNA biogenesis pathway genes are associated with semen quality in a Han-Chinese population. Reprod Biomed Online. 2012; 24:454-61.
    65）    Shen O, Liu R, Wu W (co-first author), Yu L, Wang X. Association of the methylenetetrahydrofolate reductase gene A1298C polymorphism with male infertility: a meta-analysis. Ann Hum Genet. 2012; 76:25-32.
    66）    Lu C, Zhang F, Yang H, Xu M, Du G, Wu W, An Y, Qin Y, Ji G, Han X, Gu A, Xia Y, Song L, Wang S, Jin L, Wang X. Additional genomic duplications in AZFc underlie the b2/b3 deletion-associated risk of spermatogenic impairment in Han Chinese population. Hum Mol Genet. 2011; 20:4411-21.
    67）    Shen O, Wu W (co-first author), Du G, Liu R, Yu L, Sun H, Han X, Jiang Y, Shi W, Hu W, Song L, Xia Y, Wang S, Wang X. Thyroid Disruption by Di-n-Butyl Phthalate (DBP) and Mono-n-Butyl Phthalate (MBP) in Xenopus laevis. PLoS One. 2011; 6:e19159.
    68）    Wu W, Shen O, Qin Y, Lu J, Niu X, Zhou Z, Lu C, Xia Y, Song L, Wang S, Wang X. Methylenetetrahydrofolate reductase C677T polymorphism and the risk of male infertility: a meta-analysis. Int J Androl. 2012; 35:18-24.
    69）    Wu W, Shen O, Qin Y, Niu X, Lu C, Xia Y, Song L, Wang S, Wang X. Idiopathic Male Infertility Is Strongly Associated with Aberrant Promoter Methylation of Methylenetetrahydrofolate Reductase (MTHFR). PLoS One. 2010; 5: e13884.
    70）    Wu W, Lu C, Xia Y, Shen O, Ji G, Gu A, Song L, Wang X. Lack of association between DAZ gene methylation patterns and spermatogenic failure. Clin Chem Lab Med. 2010; 48: 355-60.
    71）    Shen O, Du G, Sun H, Wu W, Jiang Y, Song L, Wang X. Comparison of in vitro hormone activities of selected phthalates using reporter gene assays. Toxicol Lett. 2009; 191: 9-14.
    72）    Lu C, Zhang J, Li Y, Xia Y, Zhang F, Wu B, Wu W, Ji G, Gu A, Wang S, Jin L, Wang X. The b2/b3 subdeletion shows higher risk of spermatogenic failure and higher frequency of complete AZFc deletion than the gr/gr subdeletion in a Chinese population. Hum Mol Genet. 2009; 18:1122-30.


    More Info.

    Editorial Board

    Mei Ling Lim
    Assistant Professor
    Karolinska Institutet
    Sweden
    mei.lim@ki.se
    AMGM

    Research Interest: Stem cells, embryonic stem cells, induced pluripotent stem cells, mesenchymal stromal cells, translational research, cell-matrix-interactions, regenerative medicine, tissue engineering.

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    Aaron Matthew Elliott
    Department of Ambry Genetics
    USA
    aelliott@ambrygen.com
    AMGM

    Research Interest: Next-Generation Sequencing, target enrichment, diagnostics, hereditary disease, targeted therapy.


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    Wenquan Niu
    Associate Professor
    Shanghai Jiao Tong University School of Medicine
    China
    niuwenquan_shcn@163.com
    AMGM

    Research Interest: Human genomics,Genetic epidemiology,Biostatistics,Evidence-based medicine.

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    Jim Jinn-Chyuan Sheu
    Professor
    Human Genetic Center China Medical University Hospital
    China
    jimsheu@mail.nsysu.edu.tw
    AMGM

    Research Interest: Cancer genetics and genomics, epigenetics, chromatin remodeling, signal transduction profiling, new drug discovery & development, complementary & alternative medicine, antibody/vaccine engineering.

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    Yan-Wei Yin
    Assistant Professor
    Department of Emergency
    Chinese PLA Air Force General Hospital
    China
    weiyyk@163.com
    AMGM

    Research Interest: Molecular genetics, Atherosclerosis, Inflammation and Meta-analysis.

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    Neslihan Saygili
    Researcher
    Department of Molecular Medicine
    Istanbul University
    Turkey
    isikeslihan@gmail.com
    AMGM

    Research Interest: Molecular cancer, pharmacogenetics, cell culture analysis.

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    Chen Chen
    Assistant Professor
    Division of Cardiology
    Huazhong University of Science and Technology
    PR China
    chenchen@tjh.tjmu.edu.cn
    AMGM

    Research Interest: The effects and mechanisms of miRNA involved in cardiocascular system and cancers; The protective effects of Arachidonic acid Cytochrome P450 epoxygenase on cardiovascular system and relevant mechanisms; Cytochrome P450 and human cancers, focus on the roles of P450 epoxygenases on proliferation, metastasis and apoptosis of human cancers, also inhibition of human cancer growth by P450 epoxygenase inhibitors.


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    Yi Zhang
    Professor
    Department of Oncology
    Zhengzhou University
    China
    yizhang@zzu.edu.cn
    AMGM

    Research Interest: Cancer treatment,) Tumor infiltrating lymphocytes ,immune cells, in tumor microenvironment,Caner stem cell,Myeloid-derived suppressor cells.

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    Ramon Cacabelos
    Professor
    Camilo Jose Cela University
    Spain
    rcacabelos@euroespes.com
    AMGM

    Research Interest: Genomics of Brain Disorders; Epigenomics; Pharmacogenomics;   Pharmacoepigenomics; Proteomics; Metabolomics; Nutrigenomics.


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    Ahmet Okay Caglayan
    Professor
    Medical Genetics and Molecular Genetics
    Dokuz Eylul University
    Turkey
    okaycaglayan@yahoo.com
    AMGM

    I am a Professor of Medical Genetics in Turkey and clinical geneticist with specific interest in neurodevelopmental disorders. I have extensive experience in next-generation and high-throughput molecular genetics, with special focus on the use of homozygosity mapping, linkage analysis and whole-exome sequencing in recessive forms of structural and functional abnormalities of the brain. I have successfully detected rare and somatic genetic variant identification in diverse range of diseases using high-throughput and next-generation genomics approaches at Yale. In the last five years, I have published papers in Cell, Science, Nature, Nature Genetics and Neuron including one of the first successful applications of exome sequencing in the identification of genetic basis of recessive forms of structural and functional abnormalities of the brain.

    I have served as a member of editorial boards, a reviewer in top-tier journals and conferences, and was invited to serve as a program committee member for international workshops and conferences as well. I established Medical Genetics Department and giving lectures to under and post graduate students, assisting in seminar groups or laboratories, and grading. Teaching activities are drawn from a diverse menu of lecture, laboratory, and seminar courses given at the undergraduate, graduate, and medical school level.

    Research Interest: Mendelian Inherited Diseases, Cancer, Clinical Genetics

    Number of publications: 41

    More Info.
    Anton Kiselev
    senior scientist
    Department of Ott Research Institute of Obstetrics
    D. O. Ott Research Institute of Obstetrics and Gynecology RAMS
    Russia
    ankiselev@yahoo.co.uk
    AMGM

    Research Interest: Gene therapy, non-viral gene delivery, inherited neuromuscular diseases,

    peptide-based carriers, Duchenne muscular dystrophy, polyplex, transfection, siRNA delivery,

    spinal muscular atrophy, genetic testing.

    More Info.
    Andrey A Zamyatnin
    Head
    I.M. Sechenov First Moscow State Medical University
    Russia
    zamyat@belozersky.msu.ru
    AMGM

    Research Interest: Programmed cell death, protein processing, intracellular communications, virus‐cell interactions, regulation of gene expression, RNAi, oxidative stress, aging, neurodegeneration, ophthalmology, cancer, regenerative medicine, personalized medicine, molecular markers, novel drug candidates.

    More Info.
    Marta Adonis
    Assistant Professor
    niversity of Chile
    Chile
    madonis@med.uchile.cl
    AMGM

    Research Interest: Science and Medicine.

    More Info.
    Jianxiu Yu
    Professor
    Department of Biochemistry and Molecular Cell Biology
    Shanghai Jiao Tong University School of Medicine
    China
    jianxiu.yu@gmail.com
    AMGM

    Research Interest: Non-coding RNA(miRNA/lncRNA), protein modifications, tumor suppressor, tumorigensis, metastasis, prostate cancer.

    More Info.
    Rasoul Alikhani Koupaei
    Professor
    Department of Genetic Disease
    Genetic Disease Laboratory
    USA
    rasoul.alikhani@gmail.com
    AMGM

    Research Interest: Newborn screening; Prenatal screening; Method development; Inborn Error of metabolism; Biochemical Genetics.

    More Info.
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    Table of Contents
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    mendeley

    The expression of DLGAP5 associate with progression and prognosis in glioma

    DOI Logo 10.17352/amgm.000011

    Published On: November 09, 2022 | Pages: 005 - 016

    Author(s): Kangjie Du, Yu Zhang, Mengyao He, Yalin Lu, Xingjie Chen, Hao Yu and Qiang Huang*
    Abstract View Full Article View
    mendeley

    Exome sequencing reveals a homozygous frameshift variant in CAPN3 in a Tunisian patient with a neuromuscular disorder

    DOI Logo 10.17352/amgm.000010

    Published On: September 27, 2022 | Pages: 001 - 004

    Author(s): Exome sequencing reveals a homozygous frameshift variant in CAPN3 in a Tunisian patient with a neuromuscular disorder
    Abstract View Full Article View    
    mendeley

    Cytosine extensions optimize case activity for telomere length regulation: Implications for CRISPR-based therapies – A short communication

    DOI Logo 10.17352/amgm.000009

    Published On: December 28, 2021 | Pages: 001 - 003

    Author(s): YRKM Sai*

    ORCID Logo  0000-0002-6151-5687

    Abstract View Full Article View
    mendeley

    Tumor-stroma cross talk and platelets: Curse of cancers

    DOI Logo 10.17352/amgm.000008

    Published On: October 06, 2020 | Pages: 018 - 019

    Author(s): Ashok Vikey*
    Abstract View Full Article View    
    mendeley

    A summary of the molecular testing recommended in acute myeloid leukemia

    DOI Logo 10.17352/amgm.000007

    Published On: April 18, 2020 | Pages: 012 - 017

    Author(s): Ruth Stuckey, Cristina Bilbao-Sieyro and María Teresa Gómez-Casares*
    Abstract View Full Article View    
    mendeley

    Expression of blaCTX-M2 and invA genes of Salmonella Heidelberg isolated from poultry by Qpcr

    DOI Logo 10.17352/amgm.000006

    Published On: April 16, 2020 | Pages: 006 - 011

    Author(s): Gabriella Bassi das Neves, Denise Nunes Araújo, Eduarda Pick, Dinael Simão Bitner, Maiara Cristiane Brisola, Regiane Boaretto Crecencio, and Lenita Moura Stefani*
    Abstract View Full Article View    
    mendeley

    Association of KIR haplotypes with propensity for developing chronic hepatitis B induced liver diseases (cirrhosis and hepatocellular carcinoma) and HIV-1 infection in a West African Cohort

    DOI Logo 10.17352/amgm.000005

    Published On: March 20, 2020 | Pages: 001 - 005

    Author(s): Florencia Wendkuuni Djigma, Pegdwendé Abel Sorgho, Marius Ayaovi Setor, Bolni Marius Nagalo, Bayala Bagora, Lassina Traore, Christelle WM Nadembega, Djeneba Ouermi, Albert Théophane Yonli and Simpore Jacques*
    Abstract View Full Article View    
    mendeley

    Genetic testing

    DOI Logo 10.17352/amgm.000004

    Published On: December 27, 2019 | Pages: 001 - 001

    Author(s): Roopa Bijja*
    Abstract View Full Article View
    mendeley

    New emerging Genetic Disease: A Case Study in Southeast Asia and a new interesting reason

    DOI Logo 10.17352/amgm.000003

    Published On: May 22, 2017 | Pages: 013 - 013

    Author(s): Beuy Joob* and Viroj Wiwanitkit
    Abstract View Full Article View    
    mendeley

    Influence of Concentration on Surface Tension & Viscosity of Tamarind (Tamarindus Indica) Seed Gum

    DOI Logo 10.17352/amgm.000002

    Published On: April 04, 2017 | Pages: 008 - 012

    Author(s): Sunita Thakur*, Pramod Kumar Sharma and Rishabha Malviya
    Abstract View Full Article View    

     

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    Indexing/Archiving

    Editor-in-Chief

    Francesco Marotta
    ReGenera R&D International for Aging Intervention & San Babila Clinic, Milano, Italy
    Archives of Clinical Gastroenterology
    Richard Hogston
    Leeds Beckett University, UK
    Archives of Community Medicine and Public Health
    Richard Kones
    Cardiometabolic Research Institute, USA
    Journal of Cardiovascular Medicine and Cardiology
    Lijie Dong
    Oklahoma University, USA
    Archives of Anatomy and Physiology
    M.Waheed Roomi
    Dr. Rath Research Institute
    1260 Memorex Drive, Santa Clara, USA
    Global Journal of Cancer Therapy
    Jose Manuel Ramia-Angel
    Guadalajara University Hospital , Spain
    Journal of Surgery and Surgical Research
    William CS Cho
    Queen Elizabeth Hospital, Hong Kong
    International Journal of Immunotherapy and Cancer Research
    Prof. Pierre Guertin
    Laval University, Canada
    International Journal of Pharmaceutical Sciences and Developmental Research
    Miklas Scholz
    Lund University, Sweden
    Annals of Environmental Science and Toxicology
    Marco Matteo Ciccone
    University of Bari , Italy
    Archives of Organ Transplantation

    NIH Funded Articles

    Endothelial Progenitor Cells in Breast Cancer Validity of Ratings of Perceived Exertion in Patients with Type 2 Diabetes Diabetic Retinopathy: Focus on Minority Populations Ethnic Differences in Abstinence Self-Efficacy among Recovering Individuals Buprenorphine Maintenance for Opioid Dependence in Public Sector Healthcare: Benefits and Barriers Intranuclear inclusions in conventional clear cell Renal Cell Carcinoma (RCC): A case report and review of the literature How Anterior Cruciate Ligament Injury was averted during Knee Collapse in a NBA Point Guard Variation among gari samples of some yellow cassava (Manihot esculenta Crantz) varieties for change in color during storage Neural Response During a Mechanically Assisted Spinal Manipulation in an Animal Model: A Pilot Study Hepatitis B Vaccination Rate in Patients with Diabetes: Assessment of Racial and Socioeconomic Disparity

    Research Articles

    Variants of WDR36 in Cameroonian glaucoma patients
    December 11, 2020    An application of metric system in determination of gender from lateral Lip prints
    April 21, 2020    Synergy of blood grouping and body sweating
    April 09, 2019

    Case Reports

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