Research Interest: Mechanisms of cell signaling pathway of cell death Cancer Biology Mechanisms of anti-cancer effect of cancer chemopreventive agents

Research Interest: Environmental Physiology,Cell cultures; Cell models; Cell physiology; Signal transduction; Gene expression; Proteomics; Mesenchymal stem cell biology and differentiation ; Krabbe disease, e

Dr Toma is senior research officer at Neuroscience Research Australia (NeuRA) and holds a conjoint lecturer position at School of Medical science (University of New South Wales). He obtained his PhD in human genetics at the University of Bologna (Italy) and carried out research projects in the genetics of neurodevelopmental disorders at the Wellcome Trust Centre for Human Genetics (University of Oxford, UK) and in the genetics of psychiatric and Mendelian diseases at the University of Barcelona (Spain).  Dr Toma has extensive experience in association studies, linkage studies, copy number variant (CNV) analyses and whole exome/genome sequencing. He has identified novel candidate genes for autism spectrum disorder and bipolar disorder, and suggested new genetic mechanisms.

Research Interest: Genetics of psychiatric diseases

Number of Publications: 31

Research Interest: Processos carcinogênicos e progressão de lesão. Invasão e metastáse. Processos patológicos envolvendo Papilomavirus humano (HPV) Estudos envolvendo análises citológicas e histopatológicos.

Research Interest: Molecular markers Genome, Evolutionary and Population, Genetics, Microbial Genetics

Research Interest: Biomarkers for the early detection and targeted therapeutics for triple negative breast cancer, oxidative stress and its role in linking cancer and diabetes, development of protein based biologics, clathrin coated pit-mediated endocytosis and its downstream signaling, drug delivery, syngeneic and xenografts mice model.

Research Interest: Endocrinology, Molecular Cell Biology, Medical Genetic, Biochemistry, Genomic, Bioinformatics, Drug Discovery

Research Interest: Cancer biology, Cancer biomarkers, Cancer cells, Cancer research, Copy number variants, Epigenetics, Gene expression, Genomics, Gene regulation, Human genetics, Microarray analysis, microRNA, Molecular Oncology, Transcriptomics

Research Interest: Research mainly focused on  Stem cells, cell  differentiation, and dedifferentiation, Congenital Heart Disease, Diabetic Cardiomyopathy, Pharmacology, Molecular  Genetics And Pulmonary Cardiac Regeneration.

URL: https://sites.google.com/site/drmattapallysaidulu/

List of publications:

1.  Mattapally S, Z Mattapally S, Pawlik KM, Fast VG, Zumaquero E, Lund FE, Randall TD, Townes TM, Zhang J.. Human Leukocyte Antigen Class I and II Knockout Human Induced Pluripotent Stem Cell-Derived Cells: Universal Donor for Cell Therapy. J Am Heart Assoc. 2018 Dec 4;7(23):e010239. doi: 10.1161/JAHA.118.010239.

2.  Mattapally S, Zhu W, Fast VG, Gao L, Worley C, Kannappan R, Borovjagin A, Zhang
J. Spheroids of cardiomyocytes derived from human induced-pluripotent stem cells
improve recovery from myocardial injury in mice. Am J Physiol Heart Circ Physiol.
2018 Aug 1;315 (2):H327-H339.

3.  Mattapally S, Cukier-Meisner W.K, Zhang J. (2017) Differentiation and Use of Induced Pluripotent Stem Cells for Cardiovascular Therapy and Tissue Engineering. In: Ieda M., Zimmermann WH. (eds) Cardiac Regeneration. Cardiac and Vascular Biology. Springer. DOI https://doi.org/10.1007/978-3-319-56106-6_5.

4.  Gao L, Gregorich Z, Zhu W, Mattapally S, Oduk Y, lou X, Kannappan R, Borovjagin A, Walcott G, Pollard A, Fast V, Hu X, Lloud SG, Ge Y, Zhang J: Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cellderived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine. Circulation 2017. https://doi.org/10.1161/CIRCULATIONAHA.117.030785.

5.  Zhu W, Zhao M, Mattapally S, Zhang J: CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Remuscularization of Injured Ventricle. Circulation Research 2017. 121:9. https://doi.org/10.1161/CIRCRESAHA.117.311504.

6.  Mattapally S, Nizamuddin S, Murthy KS, Thangaraj K, Banerjee SK. c.620C>T mutation in GATA4 is associated with congenital heart disease in South India. BMC Medical Genetics 2015, 16:7.

7.  Mattapally S, Singh M, Murthy KS, Asthana S, Banerjee SK. Computational modeling suggests impaired interactions between NKX2.5 and GATA4 in individuals carrying a novel pathogenic D16N NKX2.5 mutation. Oncotarget 2018_ 9 (17), 13713.

8.  Mattapally S, Banerjee SK: Nitric oxide: Redox balance, protein modification and therapeutic potential in cardiovascular system. IIOAB Journal 2011, 2:29-38.

9.  Kannappan R, Mattapally S, Pooja S, Zhang J. Transactivation Domain of P53 Regulates DNA Integrity in Human Cardiac Fibroblast Derived iPS Cells. AJP-Heart and Circ- 2018 Sep 1;315(3):H512-H521. doi: 10.1152/ajpheart.00160.2018.

10.  Pala RS, Pathipati UR, Mattapally S, Banerjee SK. Ultra-small silver nanoparticles induced ROS activated Toll-pathway against Staphylococcus aureus disease in silkworm model. Materials Science and Engineering, 2017: C 77, 990-1002.

11.  Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S, Banerjee SK. Attenuation of Insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacological Research, 2012, 66(3): 260-268.

12.  Zhao M , Fan C, Ernst PJ , Tang Y, Zhub H , Mattapally S , Oduk Y , Borovjagin AV ,
Zhou L , Zhang J, , Zhu W. Y-27632 Preconditioning Enhances Transplantation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Myocardial Infarction Mice. Cardiovascular Research, cvy207,https://doi.org/10.1093/cvr/cvy207.

13.  Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, Patra CR, Reddy PN, Banerjee SK. Hyperglycaemia Enhances Nitric Oxide Production in Diabetes: A study from Indian Patients. PLoS One. 2015 Apr 20;10(4).

14.  Nethi SK, Veeriah V, Barui AK, Rajendran S, Mattapally S, Misra S, Chatterjee S and Patra CR. Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale. 2015,7, 9760-9770.

15.  Santhoshi A, Mahendar B, Mattapally S, Sadhua P, Banerjee SK, Rao VJ. Synthesis of Thio-HeterocyclicAnaloguesfrom Baylis-Hillmann Bromides as Potent Cyclooxygenase-2 Inhibitors. Bioorg Med Chem Lett, 2014, 24 (8), 1952-1957.

16.  Ravinder M, Mahendar B, Mattapally S, Hamsini KV, Reddy TN, Rohit C, Srinivas K, Banerjee SK, Rao VJ. Synthesis and evaluation of novel 2-pyridone derivatives as inhibitors of phosphodiestarase3 (PDE3): A target for heart failure and platelet aggregation. Bioorg Med Chem Lett, 2012, 22(18): 6010-6015.

Research Interest: Analysis of genomic data including next-generation sequencing, microarrays data etc.; development of algorithms for discovery of predictive biomarkers for cancer such as gene mutation signatures and gene expression signatures; systems and computational biology for elucidating the nature of oncogenesis; inference of molecular interaction networks relevant to specific disease; inference of cancer genomic evolution based on gene mutation information; identification of synthetic lethal genes for cancer therapy.

Research Interest: Head and Neck Cancer Objetivos:Epidemiology and Head and Neck pathology. Biomarkers of prognostic in Head and Neck tumors

Research Interest: Epigenomics and pharmacogenomics in anti-cancer chemotherapy (Epi)Genetics and (epi)genomics for cancers and complex diseases