Mutations in the transmembrane channel-like gene1 (TMC1) are known to cause autosomal dominant and recessive forms of nonsyndromic hearing loss DFNA36 and DFNB7/11, respectively.
Background: Artemisia herba alba is an aromatic species very rich in secondary metabolites that can be used in traditional medicine.
The context and purpose of the study: This species suffers from the degradation of its natural habitat. The creation of collections containing diverse ecotypes is important for its preservation. This species contains essential oils which limit the extraction of DNA. The objective of this study is to optimize the DNA extraction and PCR conditions. The method will be used to evaluate the genetic diversity of Artemisia herba alba in the highlands of Western Algeria as a starting point.
Gastrointestinal stromal tumors (GISTs) are rare sporadic tumors that typically occur late in life, although they are the most common mesenchymal neoplasms of the gastrointestinal tract. GISTs are believed to originate from the Interstitial Cells of Cajal (ICC), a group of cells identified in the wall of the organs of the gastrointestinal tract, which act as a pace-maker for peristalsis and gut movements. However, familial and pediatric cases have also been reported.
