Keiji Sugiura* and Mariko Sugiura
Department of Environmental Dermatology and Allergology, Daiichi Clinic, Nittochi Nagoya Bld. 2F, 1-1 Sakae 2, Nakaku, Nagoya, 468-0008, Japan
Received: 12 January, 2016; Accepted: 20 January, 2016; Published: 23 January, 2016
Keiji Sugiura, Department of Environmental Dermatology and Allergology, Daiichi Clinic, Nittochi Nagoya Bld. 2F, 1-1 Sakae 2, Nakaku, Nagoya, 468-0008, Japan, Tel: +81-52-204-0834; Fax: +81-52-204-0834; E-mail:
Sugiura K, Sugiura M (2016) Contact Dermatitis Caused by Ginkgo. Glob J Allergy 2(1): 001-002. DOI: 10.17352/2455-8141.000011
© 2016 Sugiura K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Contact dermatitis; Allergy: Ginkgo nut; Urusiol; Autumn
We reported a female with a delayed-type allergic skin reaction caused by ginkgo nuts and trees. Patch tests showed positive reactions to ginkgo extracts and ursiol. The sensitized stage of her contact dermatitis might involve taking a walk or picking up gingko nuts, and the provocation stage might occur when walking along the street.
Ginkgo trees and maples are well known for their colorful autumn leaves, and many people in Japan enjoy seeing them in the autumn. Gingko trees produce a lot of nuts (fruit), and many people pick up these nuts when viewing ginkgo leaves in the autumn. The ginkgo nuts (fruit) are known to cause allergic contact dermatitis or to irritate the skin [1,2]. In 1963, there was an epidemic of 35 cases of contact dermatitis due to ginkgo trees and fruit among students . There have been many similar epidemics in the world. When students go to school, they take the same route every day. The roads often run beneath ginkgo trees, and students trample the ginkgo nuts in season. Here we describe a female case of contact dermatitis provoked by walking along a street lined with ginkgo trees.
A 70-year-old female, homemaker, developed erythema with vesicles on her face, neck and arms (Figures 1a,b). She took a walk every day along a street lined with ginkgo trees. A few days before she came to us for treatment, she picked up fallen gingko nuts from the street using her bare hands. One day later, she developed eruptions with itching on her cheeks, neck and arms after walking along the street with ginkgo trees without contacting the gingko trees or fruit. We treated her as a case of contact dermatitis due to ginkgo nuts or trees based on our interview with her. She underwent patch testing using Finn Chambers on Scanpor (Smart Practice Japan) according to the ICDRG criteria (readings were 48 and 72 hours later). Test materials were gingko extract (TORII PHARMACEUTICAL CO., LTD.) 10% pet. And urusiol (TORII PHARMACEUTICAL CO., LTD.) 0.002% pet. The results showed positive reactions to ginkgo extract and ursiol (48h / 72h; ++/ ++) (Figure 2). Laboratory data were in the normal range. We recommended that she did not eat ginkgo fruit or walk close to ginkgo trees.
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