Hidetoshi Takahashi1, Akemi Ishida-Yamamoto2 and Hajime Iizuka3
1Takagi Dermatological Clinic, Japan
2Department of Dermatology, Asahikawa Medical University, Japan
3Department of Dermatology, Housui Medical Center, Japan
Received: 06 September, 2016; Accepted: 22 September, 2016; Published: 23 September, 2016
*Corresponding author:
Hidetoshi Takahashi, Takagi Dermatological Clinic, Nishi 3 Minami 4-16, Obihiro, Hokkaido 0800013, Japan, Tel : +81-155-25-6733; Fax: +81-155-25-0308; E-Mail: @
Takahashi H, Ishida-Yamamoto A, Iizuka H (2016) Localized Myxedema on the Upper Eyelids in a Patient of Hypothyroidism. Int J Dermatol Clin Res 2(1): 018-018. DOI: 10.17352/2455-8605.000016
© 2016 Takahashi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hypothyroidism; Japanese; Myxedema; Mucin; Upper eyelids


Localized myxedema may be observed in hypo/hyperthyroidism [1]. However, the affected sites are usually pretibial area and the lesion on the eye lid is rare. We report a case of myxedema on the bilateral upper eyelids, which was a diagnostic clue of hypothyroidism associated with Hashimoto disease.

A 42-year-old Japanese woman presented with upper eyelid swelling of 2 months duration (Figure 1a). She did not complain muscle weakness or myalgia. She showed no dry coarse skin, tremors of the hands, thick tongue, or loss of hair. Histopathology of the skin biopsy revealed swelling of the collagen bundles with splitted individual fibers accompanied with pale material (Figure 1b), which was stained with blue with colloidal iron (Figure 1c). Laboratory investigation revealed decreased free T4 (0.88 ng/ml (1-1.8)), decreased free T3 (1.12 pg/ml (2.73-4.5)), and increased TSH (10.34 IU/ml (0.27-4.29). Anti-thyroid, anti-microsome, anti-thyrogloblin and anti-thyroid peroxidase antibodies were positive. Total cholesterol (286 mg/dl) and triglyceride (342 mg/dl) were elevated. Other laboratory findings including anti-nuclear antibody, aldolase, creatine kinase, and angiotensin-converting enzyme showed normal results. Echo examination disclosed slight but diffuse swelling of thyroid gland. Chest X-rays showed no abnormality and no malignant disease was detected in CT. The patient was diagnosed as localized myxedema with hypothyroidism due to Hashimoto disease. After three months of thyroid hormone replacement therapy, the skin lesions gradually improved accompanied with euthyrodic state. We got the informed consent form the patient.

  1. Figure 1:
    Patient’s clinical and histopathological findings. (a): Edema of bilateral upper eyelids. The arrows show the edema lesions. (b): H-E staining showed swelling of the collagen bundles with splitted individual fibers. (c): Colloidal iron stain disclosed the presence of mucin.

Localized myxedema tends to be observed in hyperthyroidism on the anteriolateral aspect of lower legs as pretibial myxedema. In hypothyroidism, generalized myxedema is usually observed with hair loss, dryness of the skin, and hoarseness. In hypothyroidism loss of eyelashes and eyebrows, especially on the temporal side, and puffiness of eyelids are the main features [2]. Mahto described the puffiness of eyelids as a significant complication of myxedema [2]. However, the reports of the eyelid myxedema in thypothroidsm are few and Ohtsuka et al., reported myxedema on the skin including both eyelids in hypothyroidism [3]. Our case is the second of localized myxedema with lesions restricted on the upper eyelids. Clinical differential diagnosis may include dermatomyositis, which was negated by laboratory findings of normal muscle enzyme activity, no increase in anti-nuclear antibody, and no liquefaction degeneration of basal cell layer of epidermis in histopathology.

We report a case of myxedema on the upper eyelids, which may be a clue of diagnosis of hypothyroidsm.

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