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Volume 1 Issue 1 - 2015 | Otolaryngology and Rhinology | ISSN: 2455-1759

Open Access Article Type: Research Article

Alteration of the Methylation Status of Urokinase Plasminogen Activator (uPA) is involved in Proliferation and Invasion of Nasopharyngeal Cancer Cells

The extracellular matrix degradation is the most important step in the process of tumor cell metastasis. Urokinase-type plasminogen activator (uPA) can catalyzes the conversion of the inactive zymogen plasminogen to the active broad-spectrum plasmin, which degrades a number of matrix proteins and also activates other proteases, including some matrix metalloproteinases.

Readmore... DOI: 10.17352/2455-1759.000004

Open Access Article Type: Research Article

Risk Factors for Asthma Hospitalization among Adults and Elderly

Joint effect of biological (pollen) and chemical air pollutants on asthma emergency room (ER) visits was analyzed for Szeged region of Southern Hungary. Our database of a nine-year period (1999-2007) includes daily number of asthma emergency room (ER) visits, and daily mean concentrations of CO, PM10, NO, NO2, O3 and SO2, furthermore two pollen variables (Ambrosia and total pollen excluding Ambrosia), as well.

Readmore... DOI: 10.17352/2455-1759.000003

Open Access Article Type: Letter to Editor

Image Guided Frontal Sinus Mapping: Our Technique

Access to the frontal sinus is challenging and both external and endoscopic approaches are described in the literature. Where an external approach is indicated, a bicoronal osteoplastic flap procedure is generally preferred as this reduces fronto-ethmoidal recess stenosis and allows obliteration if required [1].

Readmore... DOI: 10.17352/2455-1759.000002

Open Access Article Type: Procedures

Middle Ear Surgery: Pointers and Pitfalls

Careful preoperative selection of patients is one of the most important aspects to avoid complications. First, accurate audiology is essential. Audiological studies can contain inaccuracies as a result of machine, human, or calibration error. The otolaryngologist can use tuning forks judiciously to efficiently check results of the audiology.

Readmore... DOI: 10.17352/2455-1759.000001


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