MicroRNAs (miRNAs) are a family of short non-coding RNA molecules which contain about 18-24 nucleotides. miRNAs play significant regulatory roles in biological processes (cell proliferation, differentiation, survival and motility).

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Most aquatic and health management authorities need assessing the potential genotoxicity of contaminated effluent to avoid the effects of a lot chemical agents found as environmental contaminants. Previous studies report the presence of some pesticides and heavy metals in waters of Santiago River and suggest a genetic risk for residents, who lived nearby this river, so it is important determine its mutagenic risk.

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This study found that Aloe vera mucilage administration significantly improved biological parameters including lipids composition and oxidative stress in type 2 diabetic rats. Because the mRNA levels of lipogenic genes were significantly down-regulated (P<0.01) by the intervention of A. vera mucilage, this improvement of these biological parameters may be caused, at least in part, by the regulation of hepatic genes that are involved in lipids metabolism, thus resulting in an increase of cholesterol clearance and β-oxidation as well as a reduction of hepatic lipogenesis. The results in this study might provide a further beneficial effect of A. vera mucilage in the possible management of dyslipidemia-related diseases.

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