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Articles | Biotechnology and Biomaterial Science

Open Access Article Type: Mini Review

Important Factors Influencing Protein Crystallization

The solution of crystallization problem was introduced around twenty years ago, with the introduction of crystallization screening methods.

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Open Access Article Type: Research Article

Ruta graveolens Protects Against Isoniazid/Rifampicin-Induced Nephrotoxicity through Modulation of Oxidative Stress and Inflammation

Background and Aim: Drug-induced nephrotoxicity is a renal dyfunction that arises as a result of exposure to nephrotoxic drugs. Anti-tuberculosis therapy can cause nephrotoxicity and permanent kidney damage. The current study was designed to evaluate the possible protective effects of Ruta graveolens L. leaves extract against isoniazid/rifampicin-induced nephrotoxicity in rats.
Methods: The experimental rats received isoniazid and rifampicin at dose level of 50 mg/kg, and 50 or 100 mg/kg/day Ruta graveolens leaves extract orally for 45 days.

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Open Access Article Type: Research Article

Optimization of Sintering Conditions for Improvement of Mechanical Property of α-Tricalcium Phosphate Blocks

Bioactive ceramic materials have been under research as bone substitute for several decades. To repair the high-load bearing bones, mainly cortical bones, there is a need for the substitute to possess comparable mechanical strength to cortical bone, of which the compressive strength ranges between 100 and 230 MPa. Two prevailing bone repairing material, β-tricalcium phosphate (β-TCP, β-Ca3(PO4)2) and hydroxyapatite (HAp: Ca10(PO4)6(OH)2) have been widely researched and sintered into dense blocks to meet the mechanical requirements.

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