Anemia due to iron deficiency is commonly associated with rickets, but rarely myelofibrosis was seen in infants with rickets in the hypocalcaemic phase. The aim of this review is to elucidate the mechanism of development of myelofibrosis in rickets.

Continue reading

Introduction: Pheochromocytoma is an adrenal gland tumour, which usually produces catecholamines. The classical triad of clinical symptoms consists of palpitations, headaches and profuse sweating.

Continue reading

Gynecomastia, referred to enlargement of the male's breast tissue is a common finding in boys during childhood.

Continue reading

Introduction: Congenital hypothyroidism with muscular pseudohypertrophy or Kocher-Debre-Semelaigne syndrome is the result of long standing untreated moderate to severe hypothyroidism.

Continue reading

Introduction: Congenital generalized lipodystrophy or Berardinelli-Seip syndrome is a rare autosomal recessive multisystem disorder characterized by the near absence of subcutaneous and visceral adipose tissue from birth or early infancy with severe insulin resistance.

Continue reading

Thyroid hormones are important for early brain development. During pregnancy, both maternal and foetal thyroid hormones contribute to foetal brain development. Maternal Graves' can lead to transplacental transfer of antibodies that cause neonatal thyrotoxicosis. Neonatal thyrotoxicosis is rare and a high index of suspicion is needed to diagnose it. Neonatal thyrotoxicosis has significant risk of morbidity and mortality and early recognition is warranted.

Continue reading