Objective: In this review, we endeavor to do a literature search mainly focusing on keywords CD4+FOXP3+, CD4+CD127-, CD4+CD39+, CD4+LAP+ cancer immunotherapy, cancer immunotherapy strategies and articles published between 2015 to 2019 to add onto the minimal definition of human Treg, by an international workshop organized by collaborative immunoguiding program.
Methodology: In this review, we highlight the antitumor suppressive biomarkers of CD4+ Treg cells, how they suppress the immune response.
Summary: The biomarkers play a role in designing of cancer immunotherapy to overcome resistance and enhance anti-tumor immune response among late-stage cancer patients who have exhausted the standard of care. There is evidence suggesting that a combination of treatment strategies has enhanced immune responses for some patients who have developed or are resistant to monoclonal immunotherapy treatments.
Published on: Oct 28, 2020 Pages: 28-34
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Nikolaos A Chrysanthakopoulos
National and Kapodistrian University of Athens , Greece
Journal of Dental Problems and Solutions
Marco Matteo Ciccone
University of Bari , Italy
Archives of Organ Transplantation
Prof. Pierre Guertin
Laval University, Canada
International Journal of Pharmaceutical Sciences and Developmental Research
International Iberian Nanotechnology Laboratory (INL), Portugal
International Journal of Nanomaterials, Nanotechnology and Nanomedicine
Sassari University, Italy
Archive of Urological Research
China University of Political Science and Law, China
Forensic Science Today
Hon. Pierre Guertin
Laval University, Canada
Global Journal of Obesity, Diabetes and Metabolic Syndrome
Catholic University of Lyon, France
Annals of Cytology and Pathology
Peter J Catalano
Tufts University, USA
Archives of Otolaryngology and Rhinology
William CS Cho
Queen Elizabeth Hospital, Hong Kong
International Journal of Immunotherapy and Cancer Research
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