In 2009, graduated from Tianjin Medical University with a Ph.D. in immunology. In the same year, began to work in the Institute of Ophthalmology of Tianjin Medical University, where worked as a basic researcher. In 2012, went to Germany for a one-year postdoctoral research. Up to now, has undertaken and completed three national and provincial-level projects, and published a total of 66 research papers.

Research Interest:
PSF signalling pathway
Ocular neovascularization disease
Experimental autoimmune uveitis (EAU)
Mesenchymal stem cell therapy
Dentritic cells maturation and migration

Grants:

1    as a project principal: PTB-associated splicing factor (PSF) functions as a repressor of HIF-1α-mediated VEGF gene transcription by recruitment of Hakai. (NSFC Granted NO. 81570872,2016-2019)

2    as a project principal: the molecular mechanism of transcriptional inhibitor PSF suppress Human retinal microvessal endothelial cells proliferation with IGF-1 stimulation. (NSFC Granted NO. 31100991,2012-2014)

3    as the participant :Identification the miRNAs related with the differentiation of ESCs into RPE cells and theit effect on JUN passway. (NSFC Granted NO. 30973255, 2011-2013).

List of Publications:
English Journal:

1. Dong, L., Zhang, X., Fu, X., Zhang, X., Gao, X., Zhu, M., . . . Yang, J. (2011). PTB-associated splicing factor (PSF) functions as a repressor of STAT6-mediated Ig epsilon gene transcription by recruitment of HDAC1. J Biol Chem, 286(5), 3451-3459. doi:10.1074/jbc.M110.168377（co-first author）
2. Liu, X., Dong, L., Zhang, X., Wang, B., Wang, X., Li, H., . . . Yang, J. (2011). Identification of p100 target promoters by chromatin immunoprecipitation-guided ligation and selection (ChIP-GLAS). Cell Mol Immunol, 8(1), 88-91. doi:10.1038/cmi.2010.47（co-first author）
3. WB, L., MW, M., LJ, D., F, W., LX, C., biology, L. X. J. C., & therapy. (2011). MicroRNA-34a targets notch1 and inhibits cell proliferation in glioblastoma multiforme. 12(6), 477-483. (co-author)
4.Li WB, Z. Y., Lu ZY,  Dong LJ,  Wang FE,  Dong R,  Li XR. (2012). Development of retinal pigment epithelium from human parthenogenetic embryonic stem cells and microRNA signature. Invest. Ophthalmol. Vis. Sci., 53(9). doi:10.1167/iovs.12-8303  (co-author)
5.LJ, Z., Y, Z., LJ, D., & ophthalmology, L. X. J. C. j. o. (2012). [Expression and function of microRNA in the eye]. 48(12), 1136-1140. (co-author)
6. Tian, F., Dong, L., Zhou, Y., Shao, Y., Li, W., Zhang, H., & Wang, F. (2014). Rapamycin-Induced apoptosis in HGF-stimulated lens epithelial cells by AKT/mTOR, ERK and JAK2/STAT3 pathways. Int J Mol Sci, 15(8), 13833-13848. doi:10.3390/ijms150813833（co-first author）
7.Wei, R., Dong, L., Xiao, Q., Sun, D., Li, X., & Nian, H. (2014). Engagement of Toll-like receptor 2 enhances interleukin (IL)-17(+) autoreactive T cell responses via p38 mitogen-activated protein kinase signalling in dendritic cells. Clin Exp Immunol, 178(2), 353-363. doi:10.1111/cei.12405（co-first author）
8.Zhang, L., Dong, L., Liu, X., Jiang, Y., Zhang, L., Zhang, X., . . . Zhang, Y. (2014). alpha-Melanocyte-stimulating hormone protects retinal vascular endothelial cells from oxidative stress and apoptosis in a rat model of diabetes. PLoS One, 9(4), e93433. doi:10.1371/journal.pone.0093433 (co-author)
9.Zhang, L., Zheng, H., Shao, H., Nian, H., Zhang, Y., Bai, L., . . . Zhang, X. (2014). Long-term therapeutic effects of mesenchymal stem cells compared to dexamethasone on recurrent experimental autoimmune uveitis of rats. Invest Ophthalmol Vis Sci, 55(9), 5561-5571. doi:10.1167/iovs.14-14788 (co-author)
10.T, L., L, Z., B, Z., L, X., J, L., L, D., & reports, H. Y. J. O. (2015). Establishment and characterization of a cell line from human adenoid cystic carcinoma of the lacrimal glands and a nude mouse transplantable model. 33(6), 2797-2806. (co-author)
11.Dong, L., Nian, H., Shao, Y., Zhang, Y., Li, Q., Yi, Y., . . . Li, X. (2015). PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy. Cell Tissue Res, 360(2), 233-243. doi:10.1007/s00441-014-2104-5 (the first author)
12.Shao, Y., Dong, L. J., Zhang, Y., Liu, H., Hu, B. J., Liu, J. P., & Li, X. R. (2015). Surgical induced astigmatism correlated with corneal pachymetry and intraocular pressure: transconjunctival sutureless 23-gauge versus 20-gauge sutured vitrectomy in diabetes mellitus. Int J Ophthalmol, 8(3), 528-533. doi:10.3980/j.issn.2222-3959.2015.03.16 （co-first author）
13. Y, S., C, S., JT, W., B, D., LJ, D., AH, L., . . . medicine, e. (2015). Temporal and spatial changes in VEGF, αA- and αB-crystallin expression in a mouse model of oxygen-induced retinopathy. 8(3), 3349-3359. (co-author)
14.PT, Z., LJ, Z., H, S., LL, B., B, Y., C, S., . . . ophthalmology, Z. X. J. I. j. o. (2016). Therapeutic effects of mesenchymal stem cells administered at later phase of recurrent experimental autoimmune uveitis. 9(10), 1381-1389. (co-author)
15.W, L., L, D., M, M., B, H., Z, L., X, L., . . . therapy. (2016). Preliminary in vitro and in vivo assessment of a new targeted inhibitor for choroidal neovascularization in age-related macular degeneration. 10(undefined), 3415-3423.（co-first author）
16.X, C., H, S., Y, Z., Q, X., C, S., L, D., . . . development. (2016). CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses. 25(4), 337-346. (co-author)
17.H, T., LY, H., F, T., LJ, D., & ophthalmology, Z. H. J. C. j. o. (2017). [Effects of SMP-30 overexpression on apoptosis of human lens epithelial cells induced by ultraviolet B irradiation]. 53(11), 835-841. (co-author)
18.L, B., H, S., H, W., Z, Z., C, S., L, D., . . . reports, Z. X. J. S. (2017). Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis. 7(1), 4323. (co-author)
19. X, W., Y, Z., L, Z., R, W., & vision, D. L. J. M. (2017). Comparison of fibrin glue and Vicryl sutures in conjunctival autografting for pterygium surgery. 23(undefined), 275-285. (co-author)
20. L, D., X, C., H, S., L, B., X, L., & medicine, Z. X. J. C. m. (2018). Mesenchymal Stem Cells Inhibited Dendritic Cells Via the Regulation of STAT1 and STAT6 Phosphorylation in Experimental Autoimmune Uveitis. 17(7), 478-487. (the first author)
21. T, M., LJ, D., XL, D., R, N., & ophthalmology, H. B. J. I. j. o. (2018). Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy. 11(9), 1550-1554.
22.X, X., L, H., Y, L., X, L., R, S., X, L., & research, D. L. J. C. e. (2019). DL-3-n-butylphthalide Protected Retinal Müller Cells Dysfunction from Oxidative Stress. undefined(undefined), 1-9. (co-author)
23. Y, S., LJ, D., Y, T., J, C., X, L., Q, C., . . . metabolism. (2019). miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy. 316(3), E443-E452. （co-first author）
24.G, S., R, H., L, Z., X, S., K, H., L, D., . . . failure, K. Y. J. R. (2019). The effect of hemodialysis on ocular changes in patients with the end-stage renal disease. 41(1), 629-635. (co-author)

Chinese Journal

1、Tian Fang，Hu Bojie，Li Wenbo，Huang Liangyu，Gao Meizi，Su Ruihong，Zhang Xiaomin，Li Xiaorong，Dong Lijie. Effects of polypyramidine tract binding protein-associated splicing factor overexpression on apoptosis of human Müller cells under advanced glycation end products treatment. Chin J Ocul Fundus Dis， 2019，35（1）：  70-752. (co-author)

2、Xing Xiaoli, Huang Liangyu, Dong Lijie, Li Xiaorong. In vivo labeling and imaging of retinal ganglion cell. Int Rev Ophthalmol，2019， 43（2）： 73-78. (co-author)

3、Zhao Jinzhi, Liu Boshi, Dong Lijie, Li Xiaorong. A case of unexplained binocular retinoschisis.  Chin J Ocul Fundus Dis， 2018，34，（6）：  599-600. (co-author)

4、Niu rui, Dong lijie, Ma Teng, Du Xueli, He Yanhua, Cui Weina, Hu Bojie. Construction of connective tissue growth factor recombinant interference vector lentiviral particle and its inhibitory effect on endogenous connective tissue growth factor expression in retinal vascular endothelial cells. Chin J Ocul Fundus Dis ，2018， 34（6）： 580-585. (co-author)

5、Xie Nuotian, Bai Lingling, Yang Jing, Li Yongtao, Dong Lijie, Ma Feifei, LI Xiaorong, Zhang Xiaomin. Effects of rat mesenchymal stem cell-derived exosomes on rat experimental autoimmune uveitis.  Chin J Ocul Fundus Dis， 2018， 34（6）： 562-567 . (co-author)

6、Xing Xiaoli, Huang Liangyu, Su Ruihong, Liu Xun, Zhao Jinzhi, Gao Meizi, Zhang Xiaomin, Li Xiaorong, Dong Lijie. Effect of dl-3-n-Butylphthalide on apoptosis of retinal müller cells induced by hydrogen peroxide. Chin J Ocul Fundus Dis，2018， 34（5）： 481-486. (co-author)

7、Zhang Zhe, Liu Zhuqing, Liu Juping, Dong Lijie, Zhu Yimeng, Huang Liangyu, Su Ruihong, Zhao Jinzhi, Zhang Xiaomin, Li Xiaorong. The synergistic effect of metformin and anti-vascular endothelial growth factor in the treatment of diabetic retinopathy. Chin J Ocul Fundus Dis， 2018， 34（5）： 453-457 . (co-author)

8、Zhang Zhe，Liu Juping, Dong Lijie, Liu Zhuqing, Huang Liangyu, Su Ruihong, Zhao Jinzhi, Zhang Xiaomin, Li Xiaorong. RNA-Seq analysis of gene expression profiling in retinal vascular endothelial cells under high glucose condition. Chin J Ocul Fundus Dis， 2018，34（4）： 377-381. (co-author)

9、Niu Rui, Dong Lijie, Ma Teng, Du Xueli, Cui Weina, Hu Bojie, RNA-Seq analysis of gene expression profiling in human retinal vascular endothelial cells after anti-vascular endothecial growth factor treatment.  Chin J Ocul Fundus Dis， 2018，34（3）： 275-280 . (co-author)

10、Tian Fang, Li Webo, Huang Liangyu, GaoMeizi, Zhao Jinzhi, Hu Bojie, Zhang Xiaomin, Li Xiaorong, Dong Lijie. The effect of polypyrimidine tract binding protein-associated splicing factor on hydrogen peroxide induced apoptosis of retinal pigment epithelial.  Chin J Ocul Fundus Dis， 2018，34（2）： 159-163 . (co-author)

11、Ma Jiwei, Wang Hongtian, Liu Haofei, Dong Leipeng, Ding Yuan, Bai Jiqiong, Zhang Zhu, Dong Lijie. Effects of centellaasiatica granule on the expression of Smad 2/3, Smad 7 and collagen Ⅳ in the mesangial cells stably expressed TGF-β1, Chin J Appl Physiol ，2018， 34（2）：122-125,149. (co-author)

12、Zhang Xiaotian, Dong Lijie, Tian Fang, Zhang Hong. Observation and analysis of nonsteroidal drugs in preventing intraoperative miosis of femtosecond assist cataract surgery. Rec Adv Ophthalmol，2016，36（5）： 457-460 . ((co-author)

13、Zhang Xiaotian, Dong Lijie, Tian Fang, Zhang Hong. Observation and analysis of nonsteroidal drugs in preventing intraoperative miosis of femtosecond assist cataract surgery. Rec Adv Ophthalmol，2016，36（5）： 457-460. (co-author)

14、Bo Qiyu, Dong Lijie, Zhang Yan, Zhou Yu, Liu Xun, Han Qian, Wang Fei. MicroRNA expression profiling in a mouse model of oxygen-induced retinopathy.  Chin J Ocul Fundus Dis， 2015，31（1）： 77-82. (co-author)

15、Bai Lingling, Zhang Lingjun, Zheng Hui, Wang Yanmei, Dong Lijie, Li Xiaorong, Zhang Xiaomin,. Inhibitory effects of mesenchymal stem cells on antigen-specific T cells and antigen presenting cells in experimental autoimmune uveitis. Chin J Exp Ophthalmol，2015，33（10）： 870-875.  (co-author)

16、Qi Chen, Guo Ruru, Dong Lijie, Zhang Xiaomin, Li Xiaorong.  Application of PSF in ophthalmology. Int Rev Ophthalmol， 2015，39（3）： 195-199 . (co-author)

17、Hua Ning, Liu Hongwei, Qian Xuehan, Dong Lijie, Wu Jingjing, Li Xiaorong. The effect of semaphorin 3A in the process of apoptosis in oxygen induced retinopathy in rats.  Chin J Ophthalmol， 2014，（6）： 440-447. (co-author)

18、Tian Fang, Dong Lijie, Zhou Yu, Wang Fei, Zhang Xiaomin, Li Xiaorong. Inhibition of oxygen induced retinal neovascularization by recombinant adeno-associated virus-polypyrimidine tract-binding protein-associated splicing factor intraocular injection in mice.  Chin J Ocul Fundus Dis， 2014，30（5）： 504-508 . (co-author)

19、Wu Jingjing, Hua Ning, Dong Lijie, Li Xiaorong, Construction of bone marrow mesenchymal stem cells modified by ciliary neurotrophic factor gene in SD rat.  Chin J Exp Ophthalmol， 2014，32（5）： 392-397. (co-author)

20、Zhou Yu, Dong Lijie, Zhang Jie, Tian Fang. Pilot study on suppression of Krüppel-like factor 6 for proliferation of human lens epithelial cells．Chin J Exp Ophthalmol， 2014，32（4）： 325-330 . (co-author)

21、Li Wenbo, Li Xiaorong, Lu Zhenyu, Zhang Zhenshan, Dong Lijie, Wang Fei, Dong Rong. Expression of miR-204 and 211 in human embryonic stem cells differentiated into retinal pigment epithelial cells．　Chin J Ocul Fundus Dis， 2013，29（1）： 72-75 . (co-author)

Dong Lijie, Li Xiaodong, He Jinyan, Yao Zhi, Yangjie. Construction and Expression of pEGFP-C2-PSF Recombinant Plasmid．　J Med Mol Biol.， 2009，6（3）： 235-238 . (the first author)

23、Li Xiaodong, Fang Jianfei, Dong Lijie, Ge Lin, He Jinyan, Yang Jie．Construction and Expression of pEGFP-hSnu114 Recombinant Plasmid．J Med Mol Biol.，2009， 6（1）： 6-8 . (co-author)

Ge lin, He Jinyan, Shao Jie, Dong Lijie, Fang Jianfei, Li Xiaodong, Yang Jie. The construction and expression of GST-G3BP Domain 1～5 fusion plasm+A2:A23id in procaryote．Jouｒｎal of Tianjin Medical Univeｒｖity，2008，14（1）：1-4,21. (co-author)

25、Liu Aihua, Gao Meizi, Huang Liangyu, Liu Xun，Su Ruihong, Zhao Jinzhi, Wang Liming, Zhang Xiaominl, Li Xiaorong，Dong Lijie.(2019). The inhibitory effect of FoxF2 shRNA on the expression of extracellular matrix of human trabecular meshwork, Chin J Exp Ophthalmol,37(6),405-410.(co-author)

26、Tian Fang，Zhao Jinzhi，Huang Liangyu, Xu Manhong, Zhang Zhe, Teng He, Zhang Xiaomin , Li Xiaorong, Dong Lijie, Zhang Hong.(2019) Effects of Krüppel-like factor 6 overexpression towards apoptosis of human lens epithelial cells with ultra violetradiation B treatment, Chin J Exp Ophthalmol,37(4), 257-262.(co-author)

27、Gao Meizi，Huang Liangyu，Dong Lijie，Yang Guang，Tian Fang.(2018）Regulation of Krüppel-like Factor 6 on TGF-β1-induced fibrosis of lens epithelial cells, Journal of Traditional Chinese Ophthalmology.(co-author)

28、Tian Fang, Zhao Jinzhi, Teng He，Huang Liangyu，Liu Xun，Su Ruihong，Gao Meizi，Zhang Xiaomin, Li Xiaorong, Dong Lijie, Zhang Hong.(2018). Regulation of Krüppel-like factor 6 via activating transcription factor 4 pathway to apoptosis of human lens epithelial cells, Chin J Exp Ophthalmol,36(3) 181-186.(co-author)

29、Teng He, Huang Liangyu, Tian Fang, Dong Lijie, Zhang Hong.(2017). Effects of SMP-30 overexpression on apoptosis of human lens epithelial cells induced by ultraviolet B irradiation, Chin J Ophthalmol, 53(11) 835-841.(co-author)

30、Tian Fang，Dong Lijie，Ji fie，Zhou Yu，Li Wenbo，Bai Lingling，Wang Fei，Qi Chen，Su Chang，Zhang Xiaomin, Li Xiaorong.(2016). Inhibition of PTB-associated splicing factor on IGF-1／VEGF signaling pathway in retinal vascular endothelial cells, Chin J Exp Ophthalmol, 34(1) 11-16. (co-author)

31、Qi Chen, Dong Lijie, Le Yi, Zhang Xiaomin, Li Rongrong, Guo Ruru, Zhu Yusha, Su Chang.(2015). The regulation of PTB-associated splicing factor on phosphatidylinositol 3 kinase/Akt signaling pathway in retinal pigment epithelial cells, Chin J Ocul Fundus Dis, 31(4)363-367. (co-author)

32、Yang Liyuan, Bian Lingzhai, LI Xue, Nian Hong, Dong Lijie, Wei Ruihua.(2015). Establishment of rabbit autoimmune dry eye model and studies of lacrimal cytokines, Rec Adv Ophthalmol, 35(9) 810-815. (co-author)

33、Yang Liyuan, Bian Lingzhai, LI Xue, Nian Hong, Dong Lijie, Wei Ruihua.(2015). Establishment of rabbit autoimmune dry eye model and studies of lacrimal cytokines, Rec Adv Ophthalmol, 35(9) 810-815. (co-author)

34、Zhang Lijuan, Zhang Yan, Dong Lijie, Li Xiaorong.(2012).Expression and function of microRNA in the eye, Chin J Ophthalmol, 48(12) 1136-1140. (co-author)

35、Liu Bo, Dong Liang, LI Ying, Hao Yongna, Wei Ruihua, Dong Lijie.(2012).Construction and expression of recombinant pEGFP-C2-FOXCl-C plasmid, Journal of Tianjin Medical University, 18(2) 148-154. (co-author)

36、Wang Yue, Yang Jie , Gao yan, Dong Lijie, Yao Zhi .(2008). Regulation of estrogen, interleukin-6 and interleukin-8 in ovarian cancer cells, Chin J Microbiol Immunol, 28(9) 799-804. (co-author)

37、Ge Tin, Bu Tianxu, He Jinyan, Shao Jie, Dong Lijie, Fang Jianfei, Li Xiaodong, Sun Xiaoming, Yang Jie. (2008). The Transfection and Expression of pEGFP-CI-G3BP in Hela Cells, Tianjin Med J, 36(7) 484-485. (co-author)

38、HE Jinyan, Dong Lijie, Ge Lin, Zhao Gang, Shao Jie, Lu Yanxin, LI Xiaodong, Yao Zhi, Yang Jie.(2008).Construction and expression of a pEGFP-C2-p100 recombinant plasmid, Jounal of Tianjin Medical University, 14(2) 135-137 . (co-author)

39、Wang Yue, Yang Jie, Gao Yan, Dong Lijie, Yao Zhi .(2008). IL-6 or IL-8 enhanced AR expression in ovarian carcinoma cells depends on MAPK pathway or Src activation, IMMUNOLGICAL JOURNAL, 24(4) 424-429. (co-author)

40、He Jinyan, Ge Lin, Shao Jie, Zhao Gang, Dong Lijie, Fang Jianfe, Yao Zhi, Yang Jie.(2008). Effects of the Stable Down-Expression of Human P100 Protein on Cell Cycle in HeLa Cell Line, J Med Mol Biol, 5(3) 240-243. (co-author)

41、Da Yurong, Yao Zhi, Li Jingya, Yan Jie, Shen Qiang, Dong Lijie, Li Jia, Yang Jie.(2006).Identification of inhibitors that target JAK-STAT6 signal pathway via high-throughput screening, Chinese Pharmacological Bulletin, 22(8) 943-947. (co-author)

42、 Dong Lijie, Xing Donghong, Bai Hong, Bu Tianxu, Yao Zhi, Yang Jie.(2006).Preparation of Specific Antibody Against Human P100 Protein-A NovaI Transcription Co-activator, Tianjin Med，34(11) 786-788. (the first author)