My name is Guichuan Lai, a medical doctor, currently working in the department of health statistics at Chongqing Medical University. I have published 16 SCI papers in the past 2 years, and served as a longtime reviewer for Frontiers, BMC, Springer, and the Elsevier. My research area is exploring biomarkers of diseases using bioinformatics and network science methods, including single-cell sequencing technology, network medicine technology, and machine learning methods. Finally, I hope to be able to create value for the journal through my own experience. Here are the SCI articles I have published in the last two years:

Research Interests:

My research interest is exploring biomarkers of diseases using bioinformatics and network science methods, including single-cell sequencing technology, network medicine technology, and machine learning methods.

List of Publications:

1. Lai G, Li K, Deng J, Liu H, Xie B, Zhong X. Identification and Validation of a Gene Signature for Lower-Grade Gliomas Based on Pyroptosis-Related Genes to Predict Survival and Response to Immune Checkpoint Inhibitors. J Healthc Eng. 2022 Apr 30;2022:8704127. doi: 10.1155/2022/8704127. PMID: 35535221; PMCID: PMC9078805.
2. Lai G, Liu H, Deng J, Li K, Xie B. A Novel 3-Gene Signature for Identifying COVID-19 Patients Based on Bioinformatics and Machine Learning. Genes (Basel). 2022 Sep 8;13(9):1602. doi: 10.3390/genes13091602. PMID: 36140771; PMCID: PMC9498787.
3. Lai G, Zhong X, Liu H, Deng J, Li K, Xie B. Development of a Hallmark Pathway-Related Gene Signature Associated with Immune Response for Lower Grade Gliomas. Int J Mol Sci. 2022 Oct 9;23(19):11971. doi: 10.3390/ijms231911971. PMID: 36233273; PMCID: PMC9570050.
4. Lai G, Zhong X, Liu H, Deng J, Li K, Xie B. A Novel m7G-Related Genes-Based Signature with Prognostic Value and Predictive Ability to Select Patients Responsive to Personalized Treatment Strategies in Bladder Cancer. Cancers (Basel). 2022 Oct 29;14(21):5346. doi: 10.3390/cancers14215346. PMID: 36358764; PMCID: PMC9656096.
5. Lai G, Liu H, Deng J, Li K, Zhang C, Zhong X, Xie B. The Characteristics of Tumor Microenvironment Predict Survival and Response to Immunotherapy in Adrenocortical Carcinomas. Cells. 2023 Feb 27;12(5):755. doi: 10.3390/cells12050755. PMID: 36899891; PMCID: PMC10000893.
6. Chi H, Xie X, Yan Y, Peng G, Strohmer DF, Lai G, Zhao S, Xia Z, Tian G. Natural killer cell-related prognosis signature characterizes immune landscape and predicts prognosis of HNSCC. Front Immunol. 2022 Oct 3;13:1018685. doi: 10.3389/fimmu.2022.1018685. PMID: 36263048; PMCID: PMC9575041.
7. Zhao S, Zhang L, Ji W, Shi Y, Lai G, Chi H, Huang W, Cheng C. Machine learning-based characterization of cuprotosis-related biomarkers and immune infiltration in Parkinson's disease. Front Genet. 2022 Oct 17;13:1010361. doi: 10.3389/fgene.2022.1010361. PMID: 36338988; PMCID: PMC9629507.
8. Zhao S, Chi H, Ji W, He Q, Lai G, Peng G, Zhao X, Cheng C. A Bioinformatics-Based Analysis of an Anoikis-Related Gene Signature Predicts the Prognosis of Patients with Low-Grade Gliomas. Brain Sci. 2022 Oct 5;12(10):1349. doi: 10.3390/brainsci12101349. PMID: 36291283; PMCID: PMC9599312.
9. Zhao S, Ji W, Shen Y, Fan Y, Huang H, Huang J, Lai G, Yuan K, Cheng C. Expression of hub genes of endothelial cells in glioblastoma-A prognostic model for GBM patients integrating single-cell RNA sequencing and bulk RNA sequencing. BMC Cancer. 2022 Dec 6;22(1):1274. doi: 10.1186/s12885-022-10305-z. PMID: 36474171; PMCID: PMC9724299.
10. Xie B, Li K, Zhang H, Lai G, Li D, Zhong X. Identification and validation of an immune-related gene pairs signature for three urologic cancers. Aging (Albany NY). 2022 Feb 10;14(3):1429-1447. doi: 10.18632/aging.203886. Epub 2022 Feb 10. PMID: 35143414; PMCID: PMC8876921.
11. Liu H, Lai G, Shi G, Zhong X. The Influencing Factors of HIV-Preventive Behavior Based on Health Belief Model among HIV-Negative MSMs in Western China: A Structural Equation Modeling Analysis. Int J Environ Res Public Health. 2022 Aug 17;19(16):10185. doi: 10.3390/ijerph191610185. PMID: 36011822; PMCID: PMC9407807.
12. Chi H, Peng G, Yang J, Zhang J, Song G, Xie X, Strohmer DF, Lai G, Zhao S, Wang R, Yang F, Tian G. Machine learning to construct sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with uveal melanoma. Front Endocrinol (Lausanne). 2022 Dec 8;13:1056310. doi: 10.3389/fendo.2022.1056310. PMID: 36568076; PMCID: PMC9772281.
13. Zhang Z, Lai G, Sun L. Basement-Membrane-Related Gene Signature Predicts Prognosis in WHO Grade II/III Gliomas. Genes (Basel). 2022 Oct 7;13(10):1810. doi: 10.3390/genes13101810. PMID: 36292695; PMCID: PMC9602375.
14. Zhao S, Chi H, Yang Q, Chen S, Wu C, Lai G, Xu K, Su K, Luo H, Peng G, Xia Z, Cheng C, Lu P. Identification and validation of neurotrophic factor-related gene signatures in glioblastoma and Parkinson's disease. Front Immunol. 2023 Feb 7;14:1090040. doi: 10.3389/fimmu.2023.1090040. PMID: 36825022; PMCID: PMC9941742.
15. Zhang Y, Zhang C, Li K, Deng J, Liu H, Lai G, Xie B, Zhong X. Identification of Molecular Subtypes and Prognostic Characteristics of Adrenocortical Carcinoma Based on Unsupervised Clustering. Int J Mol Sci. 2023 Oct 23;24(20):15465. doi: 10.3390/ijms242015465. PMID: 37895143; PMCID: PMC10607826.
16. Gut microbiome dysbiosis in men who have sex with men increase HIV infection risk through immunity homeostasis alteration (Waiting for publication)