Li Wang

Associate Professor
Medical College of Wisconsin
Journal Associated: International Journal of Clinical Endocrinology and Metabolism Biography:
Research Interest: Immune-checkpoint proteins suppress tumor-specific immune responses and hamper the efficacy of cancer vaccine. My research in the past 7 years has been focused on understanding how immune-checkpoint proteins regulate anti-tumor immunity. My earlier work has identified a novel function of PD-1, an established immune-checkpoint protein in regulating the differentiation of tumor-induced adaptive Foxp3+ CD4+ regulatory T cells (PNAS, 2008). My recent work has discovered VISTA, a novel immune-checkpoint protein that critically regulates tumor-specific immunity (JEM, 2011). My ongoing work focuses on understanding VISTA-mediated immune regulation in, and designing novel combinatorial strategies that targets VISTA and additional immune-checkpoint proteins such as CTLA-4 and PD-1 for cancer immunotherapy